Don't eat chili the night before a long run, for obvious reasons. Ooh, wait, there's a proviso: if you regularly eat chili, you're probably safe to eat it before a long run.
Of course that isn't actually the real chili we ate - we used ground turkey for meat, but the beans are the same, there was minced garlic in it, chili powder, diced onions, tomatoes, etc. There were also oyster crackers and the cheese we had was more finely shredded than above, just so we're clear.
Backstory: I went over to my sister's house on Saturday night to catch up, play some Beatles Rock Band, and help her make and eat some chili. I showed her the easiest way to dice an onion, and considering she's in her 30s, I'm surprised she didn't know it already, and also how to cut fresh basil leaves. So, at least she learned something new, and I did as well (something about cost-plus). I use two knives when I cook, and I'm a firm believer that you can get by fine for most tasks with just two simple knives: 1) chef's knife (preferably 8") and a 2) paring knife. Anyhow, so we're making the chili and we sit down, start eating and catch up on her DVR, at least the shows she watches that I will watch too, like Supernatural, Burn Notice, Fringe, etc., (no Grey's, thanks!). Her Yorkie is begging next to me on the couch. The one time this dog is well-behaved is if you have some savory nom-noms on a plate or in a bowl in front of you.
Post-chili, we christened the Beatles Rock Band for Wii I had bought her for Christmas. I think I like being Ringo the most--shocker. We played quickplay for a bit then started story mode to see what things we could unlock, but it was getting late and I decided to head home.
Fast forward to Sunday morning, it was raining and cold, and I'll run when it's cold, or run when it's raining, but I don't run outside when it's rainy and cold. I have my principles (if principles = comfort level). So I went to my other sister's house to run on her treadmill, and of course my nephew comes down to the basement, he's 4, and asking what I'm going to watch on the TV while I run.
"Psych? I thought you were watching 'How I Met Your Mother?'"
He is such a well-spoken four year old. I explain that I rotate what I watch whenever I use the treadmill, all though he was right, I was watching HIMYM for a while.
Anyway, long story short, about 8 miles in I get the severe feeling right in my core, where I feel like I'm at SHITCON 2, I mean this thing is close to imminent, but I gut it out, no pun intended, and get to 9 miles before I take a break and handle my business. That was about the hardest mile I've run in my life, even though it was only at 8:20ish pace...
Anyway, lesson learned, and without going into gory detail, don't eat chili the night before a long run, and further, don't change your diet at all before a long run, don't throw your stomach a curveball, a slider, or especially a knuckleball, or you'll pay for it.